Platelet-rich plasma and its derivatives are currently used in regenerative medicine to facilitate tissue and organ repair. Products such as PRP, autologous platelet lysate, or activated PRP have been reported to accelerate tissue regeneration in diabetic ulcers, and skin retinal, and bone injuries. However, the widespread use of platelet preparations is controversial because of the large variability observed in clinical studies.
The variety of existing protocols and the lack of consistent terminology for platelet preparation make it difficult to compare the effects of tissue regeneration. Even today, many platelet products available for regenerative medicine are said to have equivalent and indistinguishable biological effects in clinical use. You can get to know more about these products in detail via 5linebiologics.com/platelet-rich-plasma.
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Some of the beneficial effects of PRP are mediated by platelet-derived growth factors such as PDGF, TGF-β1, IGF-I, FGF-2, HGF, and VEGF-A. All of these growth factors and cytokines are stored in cytoplasmic granules and released during platelet activation induced by thrombin, collagen, PAF, or calcium.
In some cases, the clot formed after PRP activation can be removed and the supernatant itself can be used as a platelet product for tissue repair therapy because it contains growth factors released by activated platelets. A large number of studies have shown that platelets and the substances they release are capable of altering the function, proliferation, and migration of various types of cells involved in tissue repairs, such as smooth muscle cells, mesenchymal stem cells, fibroblasts, and macrophages.